After spending five seasons in the Mets minor league system utility infielder Mario Ramirez finally got the call to join the big club on April 25, 1980; he entered the game as a defensive replacement at second base. Ramirez spent the rest of the season shuffling between New York and the Tidewater Tides, their AAA affiliate. In total Ramirez appeared in 18 games for the Mets during the 1980 season and batted .208 (5 for 24). His first career hit came on August 21st against the San Francisco Giants.
Following the season, the Mets lost Ramirez to the San Diego Padres in Rule 5 draft.
While with the Mets Ramirez wore both number 3 and 61.
Mario Ramirez also played for the San Diego Padres from 1981-1985.