The Mets signed right-handed pitcher Jose Santiago as a free agent on March 1, 2005. After starting the season in the minors with the Norfolk Tides, Santiago was brought up to New York in July. He made his Met debut on July 25 against the Colorado Rockies; he pitched the final two innings and allowed zero runs in the Mets 5-3 loss. He appeared in three more games before being sent back to the minors. He threw a total of 5 2/3 innings and posted a 3.18 ERA.
Following the season Santiago was granted free agency and he opted to pitch in the Mexican League. He returned to the Mets organization in 2007 and 2008 but never made it out of the minors, pitching for the New Orleans Zephyrs.
While with the Mets Santiago wore number 33.
Jose Santiago also pitched for the following teams:
Kansas City Royals – 1997-2001
Philadelphia Phillies – 2001,2002
Cleveland Indians – 2003